VP of Chemistry - Small Molecule Therapeutics Job at Aerial Talent, South San Francisco, CA

QkhHSFU4aktUVXIyZ0o4aVVFa21hV1YvRnc9PQ==
  • Aerial Talent
  • South San Francisco, CA

Job Description

Well-funded start-up in SSF seeks a Head of Medicinal Chemistry (Vice President or Executive Director) to advance our internal pipeline of small molecule therapeutics into the clinic. Experience with neurodegeneration, CNS, or other brain-penetrant therapeutics required. Experience with covalent inhibitors, bifunctionals, and molecular glues preferred.

Company Highlights:

  • Well-funded
  • Small molecule therapeutics
  • Two lead targets: CNS oncology + neurodegeneration
  • ~25 full-time employees
  • Reports to CEO

Responsibilities:

  • Lead all medicinal chemistry efforts from target validation to preclinical candidate selection and manage all chemistry project timelines
  • Design and develop small molecule compounds, libraries, and probes
  • Oversee the synthesis and optimization of platform-driven small molecules, libraries, and probes
  • Plan and oversee execution of compound scale-up for bulk intermediate supply and preclinical studies (PK/PD, efficacy, safety)
  • Manage external chemistry collaborations, including CRO chemistry programs and CMOs
  • Provide scientific and strategic leadership for medicinal chemistry programs, leading and mentoring chemists and driving the progression of compounds from discovery through IND and into the clinic
  • Develop and contribute to our intellectual property (IP) domain by way of patents and/or publications
  • Stay at the forefront of scientific advancements, including AI/ML-driven drug discovery and emerging therapeutic modalities
  • Join the Scientific Leadership Team and serve as a scientific leader, mentor, and subject matter expert (SME) on multiple project teams
  • Represent in our board meetings, investor meetings and partnering discussions

Qualifications:

  • PhD in synthetic organic chemistry with 10+ years of industry experience in drug discovery
  • Deep expertise in small molecule medicinal chemistry (synthetic organic chemistry, hit identification and validation, hit-to-lead, structure-based and/or pharmacophore-based drug design and lead optimization, ADME/DMPK optimization)
  • Proven track record of advancing small molecule medicinal chemistry programs leading to clinical candidates
  • Experience with neurodegeneration, CNS, or other brain-penetrant therapeutics
  • Experience with GMP manufacturing and process chemistry to support IND-enabling studies
  • Proven ability to manage external partners, including CROs and CMOs
  • Understanding of computer aided drug design (CADD) and AI/ML-driven approaches in medicinal chemistry
  • Scientifically rigorous, highly organized, and with significant attention to detail
  • Hands-on, team-oriented leader with a passion for mentoring and building high-performing teams in a fast-paced start-up environment
  • Experience with and/or openness to emerging drug modalities such as covalent inhibitors, bifunctionals, and molecular glues

Job Tags

Full time,

Similar Jobs

Holman Motors Inc.

Customer Service Advisor (Annual Pay $80K Obtainable) Job at Holman Motors Inc.

Customer Service Advisor Our dealershipis looking for an individual with exceptional Organizational, Communication, Task Oriented, and Customer Relations capabilities. We need you to come in and create an environment for our customers that is positive, warm, professional...

Progreen lawn and landscape

Help Desk Manager Job at Progreen lawn and landscape

Position: Help Desk Manager at Progreen lawn and landscape Compensation: Competitive salary based on experience and qualifications with potential for bonuses and benefits Position Summary: Progreen lawn and landscape is seeking a highly motivated and experienced... 

Humana

Sr Insurance Product Content Prof Job at Humana

**Become a part of our caring community and help us put health first**Humana Healthy Horizons is seeking exceptional candidates to join our Medicaid Product Organization to support the strategic direction and growth of the Medicaid line of business. This is a unique opportunity... 

Department of Consumer Affairs

Investigator Job at Department of Consumer Affairs

 ...on the job. Position located in the Investigations and Enforcement Unit (IEU) Sacramento Field...  ...hired. The position(s) require(s) a Background Investigation be cleared prior to being...  ...to work in the United States under federal law. This amendment removes the prior... 

Think Tell Junction

Entry Level Marketing Specialist Job at Think Tell Junction

Job Advertisement for Think Tell JunctionPosition: Entry Level Marketing AgentLocation: San AntonioSalary: $64,000 - $75,000 per yearJob...  ...and verbal communication skills.* Basic understanding of digital marketing principles and social media platforms.* Ability...